Aspirin belongs to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Aspirin works by relieving pain and reducing inflammation, high temperature, and fever. It is effective for mild to moderate pain like headache, toothache, and sore throat.
1- Hypersensitivity to Aspirin or any other constituents
2- Peptic ulceration or those with a history of peptic ulceration
4- Concurrent anticoagulant therapy
5- Children under the age of 16 years
Caution should be taken in patients with asthma, allergic disease, and impairment of hepatic or renal function. Do not consume Aspirin if you have a stomach ulcer. There is a possible relation between aspirin and Reye’s syndrome when given to children. This rare disease can affect the brain and liver, and also could be fatal. For this reason, Aspirin should not be given to children unless exclusively indicated.
Concurrent use of other NSAIDs or corticosteroids may increase the likelihood of gastric side effects. Aspirin use with anticoagulants can increase the risk of bleeding. The effect of phenytoin and valproate may be enhanced by Aspirin. Delayed elimination and increased toxicity of methotrexate can occur with concomitant use of Aspirin.
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Ibuprofen is an anti-inflammatory pain killer. It is used to relieve pain and redness in conditions such as osteoarthritis, arthritis, swollen joints, frozen shoulder, bursitis, tendinitis, lower back pain, sprains, and strains. It can also be used in the treatment of other painful conditions such as toothache, pain after operations, period pain, and headache.
Do not take ibuprofen if you:
1- Are pregnant or planning to become pregnant
2- Are breast-feeding
3- Are allergic to ibuprofen
4- Have, or have had, a stomach ulcer or other gastric complaint
5- Suffer from asthma or ever had an allergic reaction after taking ibuprofen, aspirin, or other anti-inflammatory pain killers
6- Suffer from the liver, kidney disease, or heart disease
7- Have systemic lupus erythematosus
8- Suffer from a condition in which bleeding tendency increases
Things to Tell Your Doctor If you:
1- Are pregnant or planning to be pregnant
2- Suffer from any gastric problems
3- Suffer from any cardiac disorders
Most common side effects?
The most common side effects observed with ibuprofen are stomach pain, indigestion, heartburn, feeling sick, vomiting, wheezing, shortness of breath, skin rash, itching, yellowing of the eyes and/or skin, severe sore throat with high fever, blurred vision and fluid retention.
1- In patients with known hypersensitivity to anti-inflammatory pain killers
2- In patients with a history of gastrointestinal bleeding or perforation,
3- In patients with an increased tendency of bleeding.
4- Patients suffering from severe heart failure, hepatic failure, and renal failure
5- In patients during the last trimester of pregnancy
Patients with sugar intolerance are advised not to take this medication.
Elderly patients have an increased frequency of gastrointestinal bleeding and perforation, caution should be exercised in such patients.
Caution should be advised in patients receiving concomitant medications which could increase the risk of ulceration or bleeding.
Caution is required if ibuprofen is administered to patients suffering from bronchial asthma.
Ibuprofen should be used with caution in patients with impaired renal, hepatic, or cardiac function.